Hydrogen Resources

Welcome to the resources page. Here you will find links to studies, articles, and videos which you can use to learn more about hydrogen therapy and its many benefits.

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Hydrogen Studies & Research

H2 Overview Studies

Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles: https://medicalgasresearch.biomedcentral.com/articles/10.1186/s13618-015-0035-1
Comprehensive Review Study on the Clinical Effects of Hydrogen: www.scirp.org/journal/PaperInformation.aspx?PaperID=62945
Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications: https://www.ncbi.nlm.nih.gov/pubmed/25747486
Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377272/
Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine: http://www.sciencedirect.com/science/article/pii/S0163725814000941
Molecular hydrogen: a therapeutic antioxidant and beyond: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223313/
The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660246/

High Ranking Studies

Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207582/#b40-vhrm-10-591
Effects of hydrogen-rich water on aging periodontal tissues in rats: http://www.nature.com/articles/srep05534
Effects of hydrogen-rich water on depressive-like behavior in mice: http://www.nature.com/articles/srep23742
Effect of Hydrogen-Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B: http://onlinelibrary.wiley.com/doi/10.1111/cts.12076/full
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals: http://www.nature.com/nm/journal/v13/n6/full/nm1577.html
Hydrogen-rich water decreases serum LDLcholesterol levels and improves HDL function in patients with potential metabolic syndrome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679390/
Hyperbaric hydrogen therapy: a possible treatment for cancer: https://www.ncbi.nlm.nih.gov/pubmed/1166304
Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators: http://www.nature.com/articles/srep18971
Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism: http://www.nature.com/articles/npjamd20168
Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early Brain Injury following Subarachnoid Hemorrhage: Possible Role of the Akt/GSK3β Signaling Pathway: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096212
Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice: http://www.nature.com/articles/srep03273
Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial: http://onlinelibrary.wiley.com/doi/10.1002/mds.25375/abstract
The hydrogen highway to reperfusion therapy: http://www.nature.com/nm/journal/v13/n6/full/nm0607-673.html

General Health

Allergies: Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells: https://www.ncbi.nlm.nih.gov/pubmed/19766097
Antioxidant: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals: https://www.ncbi.nlm.nih.gov/pubmed/17486089
Anti-aging: Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells: https://www.jstage.jst.go.jp/article/circj/80/9/80_CJ-16-0227/_pdf
Anti-aging (Lengthening telomeres, increases telomerase expression): Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin Signaling and SIRT 1 and Telomerase Activity: http://pubs.sciepub.com/ajfn/4/6/4/index.html#.WOHa_8Tp96g.facebook
Anti-inflammatory: Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation: https://www.ncbi.nlm.nih.gov/pubmed/11510417
Burns: Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation: https://www.ncbi.nlm.nih.gov/pubmed/26047940
Burns: Protective effects of hydrogen against severe burns: http://www.molecularhydrogenstudies.com/protective-effects-of-hydrogen-against-severe-burns/
Cholesterol: Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome—An Open Label Pilot Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831093/
Hay Fever: Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model: https://www.ncbi.nlm.nih.gov/pubmed/28215576
High blood glucose: Role of hydrogen gas in regulating of poly (ADP-ribose) polymerase-1 dependent cell death in rat Schwann cells: https://www.ncbi.nlm.nih.gov/pubmed/27434555
Neuropathic pain: H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain: https://www.ncbi.nlm.nih.gov/pubmed/25820467
NrF2 Pathway (activates cell defense system): Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo: http://m.ajplung.physiology.org/content/304/10/L646.abstract
Pain (reduces heightened sensitivity to pain): Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via regulation of NR2B-containing NMDA receptor in rats: https://www.ncbi.nlm.nih.gov/pubmed/25241067
Protects against Aspirin damage: Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925872/
Protects against Tylenol damage: Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice: https://www.ncbi.nlm.nih.gov/pubmed/25892869
Seasonal allergies: Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress: https://journal-inflammation.biomedcentral.com/articles/10.1186/s12950-016-0148-x
Skin wrinkles: Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes: https://www.ncbi.nlm.nih.gov/pubmed/22070900
Smoking: Attenuation of Cigarette Smoke-Induced Airway Mucus Production by Hydrogen-Rich Saline in Rats: https://archive.org/details/pubmed-PMC3869805
Smoking: Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury: https://www.researchgate.net/publication/277937758_Protective_Effects_of_Hydrogen-Rich_Saline_on_Rats_with_Smoke_Inhalation_Injury
Supports immune system: The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice: https://www.ncbi.nlm.nih.gov/pubmed/19252295
Supports immune system: Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119399/
Wounds: Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699099/

Oxidative Stress

Oxidative stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101336/
Oxidative Stress and Antioxidant Defense: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488923/
Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation: https://www.ncbi.nlm.nih.gov/pubmed/22020111
Oxidative stress in human diseases: https://www.ncbi.nlm.nih.gov/pubmed/18924487
Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724665/
Oxidative stress and psychological disorders: https://www.ncbi.nlm.nih.gov/pubmed/24669208

Athletic Improvement

Improves heart function: Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats: https://www.ncbi.nlm.nih.gov/pubmed/26849632
Increased ATP production: Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration: http://onlinelibrary.wiley.com/doi/10.1111/j.1432-2277.2012.01542.x/full
Increased ATP production: Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury: http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0108034
Increased ATP production: Stimulation of human damaged sperm motility with hydrogen molecule: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300028/
Increased Metabolism: Molecular hydrogen stimulates the gene expression of transcriptional co-activator PGC-1α to enhance fatty acid metabolism: http://www.nature.com/articles/npjamd20168
Post recovery: Is molecular hydrogen beneficial to enhance post-exercise recovery in female athletes: https://www.researchgate.net/publication/306082536_Is_molecular_hydrogen_beneficial_to_enhance_post-exercise_recovery_in_female_athletes https://www.researchgate.net/publication/304667974_Molecular_Hydrogen_Affected_Post-Exercise_Recovery_in_Judo_Athletes_3820_Board_259_June_4_9_30_AM_-_11_00_AM
Prevents cognitive decline: Molecular Hydrogen and its Potential Application in Therapy of Brain Disorders: http://www.omicsgroup.org/journals/molecular-hydrogen-and-its-potential-application-in-therapy-of-brain-disorders-2168-975X.1000154.php?aid=36193 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872234/
Prevents Muscle fatigue/reduces lactic acid: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes: http://www.ncbi.nlm.nih.gov/pubmed/22520831
Selective antioxidant: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals: http://www.nature.com/nm/journal/v13/n6/full/nm1577.html
Sport Medicine: Molecular hydrogen in sports medicine: new therapeutic perspectives: http://www.ncbi.nlm.nih.gov/pubmed/25525953
Sport related injuries: Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries: http://www.ncbi.nlm.nih.gov/pubmed/25295663

Cancer

Hydrogen-dissolved water inhibits growth of human tongue carcinoma cells: http://www.molecularhydrogenstudies.com/hydrogen-dissolved-water-inhibits-growth-of-human-tongue-carcinoma-cells/ , http://exp-oncology.com.ua/uploads/magazine/772.pdf?upload
Hydrogen–water enhances 5-fluorouracil-induced inhibition of colon cancer: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393812/
Hyperbaric hydrogen therapy: A possible treatment for cancer: https://www.researchgate.net/publication/21989955_Hyperbaric_hydrogen_therapy_A_possible_treatment_for_cancer http://image.sciencenet.cn/olddata/kexue.com.cn/upload/blog/file/2009/2/2009210115846546222.pdf
Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice: https://link.springer.com/article/10.1007/s00280-008-0924-2
Neutral pH hydrogen-enriched electrolyzed water achieves tumorpreferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression: https://www.ncbi.nlm.nih.gov/pubmed/19192719
Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386386/
Telomere Shortening in Cancer Cells by Electrolyzed-Reduced Water: https://link.springer.com/chapter/10.1007%2F0-306-46869-7_62

Arthritis

Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563451/
Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095341/
Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788323/
Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide: https://medicalgasresearch.biomedcentral.com/articles/10.1186/2045-9912-1-18
Molecular hydrogen suppresses activated Wnt/β-catenin signaling: http://www.nature.com/articles/srep31986
Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study: https://www.ncbi.nlm.nih.gov/pubmed/24929023

Diabetes (Type 1 & 2)

Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284969/
Anti-Oxidative Water Improves Diabetes: https://link.springer.com/chapter/10.1007/978-94-010-0369-8_137#page-1
Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat mode: http://download.springer.com/static/pdf/45/art%253A10.1186%252F2045-9912-1-26.pdf?originUrl=http%3A%2F%2Fmedicalgasresearch.biomedcentral.com%2Farticle%2F10.1186%2F2045-9912-1-26&token2=exp=1489680419~acl=%2Fstatic%2Fpdf%2F45%2Fart%25253A10.1186%25252F2045-9912-1-26.pdf*~hmac=07d76ed8438f56479eef94ea3b8046f1eda6f5daa17cc5213fc0a17c2ef9875d
Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053913
Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice: https://www.ncbi.nlm.nih.gov/pubmed/21293445
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance: https://www.ncbi.nlm.nih.gov/pubmed/19083400
Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386384/
Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress: https://www.ncbi.nlm.nih.gov/pubmed/22800834
Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice: http://www.cardiovascularpathology.com/article/S1054-8807(15)00055-1/references

Heart Disease

Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?: https://www.ncbi.nlm.nih.gov/pubmed/19505462
Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart: https://www.ncbi.nlm.nih.gov/pubmed/23771690
Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats: http://www.heartlungcirc.org/article/S1443-9506(14)00800-2/references
Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice: https://www.ncbi.nlm.nih.gov/pubmed/18996093?dopt=Abstract
H2 Gas Improves Functional Outcome After Cardiac Arrest to an Extent Comparable to Therapeutic Hypothermia in a Rat Model: http://jaha.ahajournals.org/content/1/5/e003459.full
Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats: https://www.ncbi.nlm.nih.gov/pubmed/26849632
Hydrogen gas protects against serum and glucose deprivation‑induced myocardial injury in H9c2 cells through activation of the NF‑E2‑related factor 2/heme oxygenase 1 signaling pathway: https://www.spandidos-publications.com/mmr/10/2/1143
Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081383/
Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation: https://www.ncbi.nlm.nih.gov/pubmed/26565704
Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice: http://www.cardiovascularpathology.com/article/S1054-8807(15)00055-1/references

Kidney Disease

Hydrogen: another gas with therapeutic potential: http://www.kidney-international.org/article/S0085-2538(15)54214-2/fulltext
Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation: https://www.ncbi.nlm.nih.gov/pubmed/27148060
Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Lepr/NDmcr rat kidney: https://www.researchgate.net/publication/229011208_Hydrogen-rich_water_inhibits_glucose_and_ab_-dicarbonyl_compound-induced_reactive_oxygen_species_production_in_the_SHRCg-LeprNDmcr_rat_kidney
Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats: https://www.ncbi.nlm.nih.gov/pubmed/25592271
Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats: https://academic.oup.com/ndt/article/26/7/2112/1895116/Intake-of-water-with-high-levels-of-dissolved
The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives: https://rrtjournal.biomedcentral.com/articles/10.1186/s41100-016-0036-0
The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice: https://www.ncbi.nlm.nih.gov/pubmed/21570445

Mental Disorders

Effects of hydrogen-rich water on depressivelike behavior in mice: http://www.nature.com/articles/srep23742
Electrolyzed-reduced water mitigates amyloid beta toxicity via DAF-16 in C. elegans: https://link.springer.com/article/10.1007/s13530-016-0261-5
Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism: https://www.researchgate.net/publication/232225514_Hydrogen_as_a_novel_hypothesized_emerging_treatment_for_oxidative_stress_in_autism
Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress: https://www.ncbi.nlm.nih.gov/pubmed/20171955
Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells: https://www.ncbi.nlm.nih.gov/pubmed/26271894
Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680337/
Molecular Hydrogen Reduces LPS-Induced Neuroinflammation and Promotes Recovery from Sickness Behaviour in Mice: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042078
Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464164/
Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis: https://www.ncbi.nlm.nih.gov/pubmed/26537817

Parkinsons

Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407490/
Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson’s Disease: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007247
Hydrogen therapy: from mechanism to cerebral diseases: http://www.medgasres.com/article.asp?issn=2045-9912;year=2016;volume=6;issue=1;spage=48;epage=54;aulast=Liu
Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial: http://onlinelibrary.wiley.com/doi/10.1002/mds.25375/abstract
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease: https://www.ncbi.nlm.nih.gov/pubmed/19356598
Therapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease: https://www.hindawi.com/journals/pd/2011/307875/

Stroke

Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411925/
Lactulose: an effective preventive and therapeutic option for ischemic stroke by production of hydrogen: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298790/
Potential application of hydrogen in traumatic and surgical brain injury, stroke and neonatal hypoxia-ischemia: https://medicalgasresearch.biomedcentral.com/articles/10.1186/2045-9912-2-11
The hydrogen highway to reperfusion therapy: http://www.nature.com/nm/journal/v13/n6/full/nm0607-673.html